Newly Published: Can WIN 18,446 function as a nonhormonal female contraceptive? 

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Newly Published: Can WIN 18,446 function as a nonhormonal female contraceptive? 

Vitamin A deficient women produce less retinoic acid, and this deficiency reduces their fertility. Meanwhile, the compound WIN 18,446 inhibits retinoic acid production. WIN 18,446 has already been shown to have a contraceptive effect for males. 

Researchers at the University of Washington recently published the results of an animal study to test whether the compound could be used as a female nonhormonal contraceptive. While the compound did prevent all four of the mice that were fed a WIN 18,446-infused diet from giving birth, it did not entirely prevent pregnancy. One of the animals became pregnant with malformed embryos. 

While WIN 18,446 was fairly effective in preventing pregnancy, the researchers conclude that the compound’s disruption of fetal development makes its appeal as a contraceptive limited. 

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Categorised in: New R&D, Publications, Research

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